George M. Carman, Ph. D.

Han, G.-S., L. O’ Hara, G.M. Carman, and S. Siniossoglou.  2008.  An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.  J. Biol. Chem. 283: 20433-20442. Reprint (JBC Paper of the Week)

Han, G.-S., L. O’ Hara, S. Siniossoglou, and G.M. Carman.  2008.  Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.  J. Biol. Chem. 283: 20443-20453.Reprint (JBC Paper of the Week)

Nadra, K., A.-S. de Preux Charles, J.-J. Médard, W.T. Hendriks, G.-S. Han, S. Grès, G.M. Carman, J.-S.  Saulnier-Blache, M.H.G. Verheijen, and R. Chrast.  2008.  Phosphatidic acid mediates demyelination in Lpin1 mutant mice.  Genes Dev. 22, 1647-1661. Reprint

Soto, A., and G.M. Carman.  2008.  Regulation of the Saccharomyces cerevisiae CKI1-encoded choline kinase by zinc depletion. J. Biol. Chem. 283: 10079-10088. Reprint

Havriluk, T., F. Lozy, S. Siniossoglou, and G.M. Carman.  2008.  Colorimetric determination of pure Mg2+-dependent phosphatidate phosphatase activity.  Anal. Biochem.  373: 392-394. Reprint

Han, G.-S., S. Siniossoglou, and G.M. Carman.  2007.  The cellular functions of the yeast lipin homolog Pah1p are dependent on its phosphatidate phosphatase activity.  J. Biol. Chem. 282: 37026-37035. Reprint

Choi, H.-S., and G.M. Carman. 2007. Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae. J. Biol. Chem. 282: 31217-31227. Reprint

Chang, Y.-F., S.S. Martin, E.P. Baldwin, and G.M. Carman.  2007.  Phosphorylation of human CTP synthetase 1 by protein kinase C. Identification of Ser462 and Thr455 as major sites of phosphorylation.  J. Biol. Chem. 282: 17613-17622. Reprint

Choi, M.-G., and G.M. Carman.  2007.  Phosphorylation of human CTP synthetase 1 by protein kinase A. Identification of Thr455 as a major site of phosphorylation.  J. Biol. Chem. 282: 5367-5377. Reprint

O’Hara, L., G.-S. Han, S. Peak-Chew, N. Grimsey, G.M. Carman, and S. Siniossoglou.  2006.  Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. J. Biol. Chem. 281: 34537-34548 Reprint

Han, G. S., W.-I. Wu, and G.M. Carman.  2006.  The Saccharomyces cerevisiae lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.  J. Biol. Chem. 281: 9210-9218. Reprint (JBC Paper of the Week and News Release)

Kersting, M.C., and G.M. Carman.  2006.  Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion. J. Biol. Chem. 281: 13110-13116. Reprint

Chang, Y.-F., and G.M. Carman.  2006. Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p. J. Biol. Chem. 281: 4754-4761. Reprint

Han, G. S., A. Sreenivas, M.-G. Choi, Y.-F. Chang, S.S. Martin, E.P. Baldwin, and G.M.  Carman.  2005.  Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. J. Biol. Chem. 280: 38328-38336. Reprint

Han, S.-H., G.-S. Han, W.M. Iwanyshyn, and G.M. Carman.  2005.  Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc.  J. Biol. Chem. 280: 29017-29024. Reprint

Chang, F.S., G.-S. Han, G.M. Carman, and K.J. Blumer.  2005.  A WASp-binding type II phosphatidylinositol 4-kinase is required for actin polymerization-dependent endosome motility.  J. Cell Biol. 171: 133-142. Reprint

Choi, M.-G., V. Kurnov, M.C. Kersting, A. Sreenivas, and G.M. Carman.  2005. Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation. J. Biol. Chem. 280: 26105-26112. Reprint

Reviews

Chang, Y.-F., and G.M. Carman.  2008.  CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae.  Prog. Lipid Res. 47: 333-339. Reprint

Carman, G.M., and S.A. Henry.  2007.  Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae. J. Biol. Chem. 282: 37293-37297. Reprint

Carman, G.M., and G.-S. Han.  2007.  Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion.  Biochim. Biophys. Acta. 1771: 322-330. Reprint

Carman, G.M., and G.-S. Han.  2006.  Roles of phosphatidate phosphatase enzymes in lipid metabolism.  Trends Biochem. Sci. 31: 694-699. Reprint

Carman, G. M.  2005.  Regulation of phospholipid synthesis in yeast by zinc.  Biochem. Soc.Trans. 33: 1150-1153. Reprint

Carman, G.M., and M.C. Kersting.  2004.  Phospholipid synthesis in yeast: regulation by phosphorylation.  Biochem. Cell Biol. 82: 62-70. Reprint

Han, G.-S., and G.M. Carman.  2004.  Phospholipid synthesis in yeast, in Encyclopedia of Biological Chemistry (W.J. Lennarz and M.D. Lane, eds), Elsevier, Oxford. 3: 321-325.

Oshiro, J., G.-S. Han, and G.M. Carman.  2003.  Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae.  Biochim. Biophys. Acta 1635: 1-9. Reprint

Kent, C., and G.M. Carman.  1999.  Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus.  Trends Biochem. Sci. 24: 146-150. Reprint

Carman, G.M. and S.A. Henry.  1999.  Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes.  Prog. Lipid Res. 38: 361-399.

Carman, G.M., and G.M. Zeimetz. 1996. Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 271: 13292-13296. Reprint

Carman, G.M. 1997.  Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli.  Biochim. Biophys. Acta  1348: 45-55. Reprint

Carman, G.M., R.A. Deems, and E.A. Dennis. 1995. Lipid signaling enzymes and surface dilution kinetics. J. Biol. Chem. 270: 18711-18714. Reprint