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Nutrigenomics (11:400:410)

Credit: 3
Prerequisite:
Time & Place: Tuesday, 5:35 - 8:15 pm / Rm 101
Office Hours: By appointments
For appointments: call/email

Instructor:

Laura Rokosz, Ph. D.
laura.rokosz@rutgers.edu

(908) 764-9062
(732) 932-6776


(Revised on January 30, 2020)

Course Description

Nutrigenomics is the study of the interaction between nutrients and other dietary bioactives on gene expression. This rapidly emerging applied science demonstrates how common food ingredients affect health by altering the expression of genes and the structure of an individual’s genome. Through an understanding of how nutrients interact with the genome and the mechanism of action of nutraceuticals and dietary supplements in cells, novel treatment of important diseases may be addressed through improved nutrition or the development of targeted health promoting foods and beverages.

This course will explore the science of nutrigenomics and focus on those plant and animal nutraceuticals that provide important health, wellness and comfort benefits. Common ailments will be discussed along with the role bioactives play in their suppression and/or remedy. Additionally, this course will investigate the nature and type of specific nutraceuticals, their origin, mechanism(s) of action and the potential benefits they offer. We will also have an in depth look at the role that nutrients play in gut health and gut-brain interactions.

EDUCATIONAL PHILOSOPHY & INSTRUCTIONAL METHODS:

The course incorporates a variety of learning opportunities and measures. Critical thinking on food science topics related to nutrition, molecular biology, biology and chemistry are incorporated throughout. The material is technical in nature and provides students with multiple learning media, including assigned readings, class lectures and notes, videos, practical application of information, group activities, two written exams, a research report and an oral presentation via podcasting. Guest lecturers with expertise in various areas of Integrative Healthcare will share their experience in the application of Nutraceuticals and Nutrigenomics in healthcare.

Suggested and Mandatory Readingss
Mandatory text for Nutrigenomics section
  1. Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition - Edited by Lynette R. Ferguson.
  2. Nutrigenetics - Edited by Doris Corella ISBN 978-3-03842-996-8 (PDF)
  3. Suggested text for Nutrigenomics section
  4. Clinical Nutrition - A Functional Approach, Second Edition – Edited by DeAnn Liska, Sheila Quinn, Dan Lukaczer, David S. Jones, Robert H. Lerman
  5. Suggested text for Nutraceuticals section
  6. Nutraceuticals and Functional Foods – Edited by Robert Wildman
  7. Handbook of Nutraceuticals Vol I – Yashwant Pathak

GRADING
Points
Class Attendance**
5
Class Participation
10
Exams
  Exam#1 – Midterm exam
20
  Written Project on Nutrigenomics
25
  Class presentation/podcast on Nutraceutical applications
20
  Exam #2 – Final Exam
25
  Extra credit – Guest speaker report*
5
  Total
110

**You will not be penalized for class attendance but you may not earn credit if you have more than two absences.

SEMESTER COURSE OUTLINE
Date
Topic
Exam/Project
Reading Material/Assignment See Canvas for all reading materials
Jan 21
* Introductions, Review of Syllabus and Course Materials
* Introduction to Nutraceuticals and Nutrigenomics
Ferguson Chapter 1
Jan 28
Nutrigenetics and Nutrigenomics Solute Carrier SNPs
Ferguson Chapter 2
Corella pp191-207
Corella pp53-68
Feb 4
Epigenetics
Ferguson Chapter 12
Corella pp 83-99
Corella pp142-153
Feb 11
Obesity and Diabetes
Instructions for Nutrigenomics report with template
Ferguson Chapter 6
Corella pp 1-18
Feb 18
Heart Disease and Lipid Metabolism
Ferguson Chapters 3, 5
Corella 19-35
Corella 69-82
Feb 25
Inflammatory Bowel Diseases
Gut-Brain/Microbiome
Ferguson Chapters 7, 8, 9
MidTerm review
Mar 3
Midterm, open book
Lectures Jan 22-Feb 26
Multiple choice, fill-in, essays
Mar 10
Guest Lectures:
Apostolos Pappas
Skin health and nutrition
Podcast Instructions
Guest Lecture extra credit
Mar 17
Spring Break
Select topic and work on Podcast
Mar 24
Microbiome, Resistent Starch,
Rhonda Witwer
Gut Health and disease
Guest Lecture extra credit
Mar 31
Guest Lecturer: Herbal
Medicine: Dr. Glenn Gero
Hormones and Immunity
Apr 7
The Nutrigenomic Toolkit,
Precision Nutrition
Ferguson Chapters 4, 10, 11, 14 Corella 159-175
Apr 14
Cancer, Functional Foods,
Medical Foods, and GMO Foods
Corella pp 36-52
Corella 100-111
Apr 21
Foodomics, DNA testing
Crisper technology
Nutrigenomics and public health
Personalized Nutrition
Ferguson Chapter 13, 16, 18, 20, 21
Corella 131-134
Apr 28
Class podcasts
Q&A
Record Podcasts in class
Distribute Final exam: Due May 14th
May 5
Reading Period
Written report due Please place in Food Sci mailbox (in office area, not mail room)
May 12
Final exam-Take home
Lectures Mar 12-Apr 21
Podcasts
Extra credit report due
Hand in Final exam

GRADING:

GRADING GRID
"A"
= 89.5-100
"B+"
= 84.5-89.49
"B"
= 79.5-84.49
"C+"
= 74.5-79.49
"C"
= 769.5-74.49
"D"
= 59.5-69.49
"F"
= 0-59.49

"IN" grade: "Incomplete" is used only in courses offered by the graduate schools. Anyone to whom you assign an "IN" may have any time period you agreed-upon (up to one year to complete the work, but up to two years in Graduate School of Education and College of Pharmacy, Pharm.D. courses). It is your responsibility to see that the agreed-upon date is adhered to, and to Change the Grade Online. For detail go to the Student Unofficial Transcript and Grades website. "IN" becomes a permanent grade after one year, except in the Graduate School of Education where it converts to NO/CR and in the College of Pharmacy, Pharm.D. where it converts to "F" after two years.

DEPARTMENT POLICIES AND EXPECTATIONS FOR STUDENT PERFORMANCE

Graduates of the department receive degrees as food science professionals, and professional behavior constitutes a key component of our academic programs. The department expects all students – at any level and in any program to:

  • Attend classes.
  • Come to class on time.
  • Complete reading on schedule, when applicable.
  • Complete all course Readings on time.
  • Write using correct format, grammar, spelling, and reference style.
  • Turn in work that meets ethical standards and is not plagiarized.
  • Take responsibility for obtaining and making up missed work.
  • Finish all course work by the end of the semester.
  • Inform instructors in advance if classes need to be missed.
  • Provide documentation to support reasons for missing class, assignments and examinations.

Department policies

Grading: takes the above standards into consideration and applies penalties for failure to meet them. Instructors are not required to read or give a passing grade to work that is late, incomplete, or inadequately prepared

PODCASTS
  1. Working in pairs research a health concern of somewhat recent controversy and discuss how these concerns can be addressed using Nutrigenetic and Nutrigenomic data. The Podcast may be recorded during class or you may pre-record your podcast and share it during class. You will be asked why your topic is a relevant health concern? Has it been in the news lately, and if so, in what capacity? Is there any Nutrigenomic, Nutrigenetic or epigenetic data that informs on the cause and/or solution? If not, do you think these healthcare tools can be used to tease out a solution? Please explain.
  2. Limit the Podcast to no more than 20 minutes and no less than 10 minutes.
  3. Allow 5-10 min for Q & A from the class.
WRITTEN REPORT
  • The term paper will relate Nutrigenomic and Nutrigenetic concepts to one of the therapeutic areas covered during class. Other disease areas are acceptable pending approval by your professor. A template for the report will be distributed on February 11, 2020.
EXTRA CREDIT REPORT
  • You are welcome to submit a one- to two-page report summarizing the content of the guest speakers' presentations. Select ONE speaker for your report.

ACCOMODATIONS FOR STUDENTS WITH DISABILITIES

Please follow the procedures outlined at Rutgers Office Of Disability services Registration form. Full policies and procedures are found in the Rutgers Office Of Disability services website.

The Rutgers Office Of Disability services is located at Lucy Stone Hall, Suite A145, Livingston Campus, 54 Joyce Kilmer Avenue, Piscataway, NJ 08854. The contact phone number is (848) 445-6800.

Rutgers University welcomes students with disabilities into all of the University's educational programs. In order to receive consideration for reasonable accommodations, a student with a disability must contact the appropriate disability services office at the campus where you are officially enrolled, participate in an intake interview, and provide documentation at Rutgers Office Of Disability services documentation Guidelines website. If the documentation supports your request for reasonable accommodations, your campus’s disability services office will provide you with a Letter of Accommodations. Please share this letter with your instructors and discuss the accommodations with them as early in your courses as possible. To begin this process, please complete the Registration form on the ODS web site at: Rutgers Office Of Disability services Registration form.

Absence Policy

The University does recognize that temporary conditions and injuries can be problematic and may adversely affect a student’s ability to fully participate in class.

Absences or making up work go to Temporary Conditions website for detail.

The Dean of Students Office at Rutgers University-New Brunswick provides solutions, services, and support to help students navigate Rutgers University. By focusing on students’ educational, social, and personal development, staff in the Office promote academic success and student retention. The Office serves as a student support network by providing advocacy, problem resolution, and critical incident intervention for those times when additional assistance is needed.

  • Self-Reporting Absences: For absences in class or labs less than a week that are not confidential in nature, students need to inform faculty directly by using the Absence Reporting System (ARS).
  • Longer Periods of Absence: If you anticipate missing more than one week of classes for serious illness, confidential, or sensitive personal reasons, you should also consult with a New Brunswick Dean of Students who will help to verify your extended absences from classes.
  • Absences due to illnesses: If your absence is due to illness, visit New Brunswick Health Services for information about campus health services, including information about: how to make an appointment, self-care advice for colds/flu, mental health and counseling options.

ACADEMIC INTEGRITY

The university's policy on Academic Integrity requires that a student:

  • properly acknowledge and cite all use of the ideas, results, or words of others.
  • properly acknowledge all contributors to a given piece of work.
  • make sure that all work submitted as his or her own in a course or other academic activity is produced without the aid of impermissible materials or impermissible collaboration.
  • obtain all data or results by ethical means and report them accurately without suppressing any results inconsistent with his or her interpretation or conclusions.
  • treat all other students in an ethical manner, respecting their integrity and right to pursue their educational goals without interference. This requires that a student neither facilitate academic dishonesty by others nor obstruct their academic progress.
  • uphold the canons of the ethical or professional code of the profession for which he or she is preparing.

Adherence to these principles is necessary in order to ensure that

  • everyone is given proper credit for his or her ideas, words, results, and other scholarly accomplishments.
  • all student work is fairly evaluated, and no student has an inappropriate advantage over others.
  • the academic and ethical development of all students is fostered.
  • the reputation of the University for integrity in its teaching, research, and scholarship is maintained and enhanced.

Failure to uphold these principles of academic integrity threatens both the reputation of the University and the value of the degrees awarded to its students. Every member of the University community therefore bears a responsibility for ensuring that the highest standards of academic integrity are upheld.

Cheating and Plagiarism

(From Spring 2010 Andy Egan 01:730:252 Eating Right): "Cheating on tests or plagiarizing materials in your papers deprives you of the educational benefits of preparing these materials appropriately. It is personally dishonest to cheat on a test or to hand in a paper based on unacknowledged words or ideas that someone else originated. It is also unfair, since it gives you an undeserved advantage over your fellow students who are graded on the basis of their own work. In this class we will take cheating very seriously".

Turnitin will be used to assess students‚ submissions and all suspected cases of cheating and plagiarism will be automatically referred to the Rutgers Academic Integrity office.

Just In Case Web App

Counseling, ADAP & Psychiatric Services (CAPS)

Counseling, ADAP & Psychiatric Services (CAPS) located at 17 Senior Street, New Brunswick, NJ 08901 is a University mental health support service that includes counseling, alcohol and other drug assistance, and psychiatric services staffed by a team of professional within Rutgers Health services to support students’ efforts to succeed at Rutgers University. CAPS offers a variety of services that include: individual therapy, group therapy and workshops, crisis intervention, referral to specialists in the community and consultation and collaboration with campus partners. its phone number is (848) 932-7884.

Violence Prevention & Victim Assistance (VPVA)

The Violence Prevention & Victim Assistance (VPVA) phone number is (848) 932-1181, and it is located at 3 Bartlett Street, New Brunswick, NJ 08901

The Office for Violence Prevention and Victim Assistance provides confidential crisis intervention, counseling and advocacy for victims of sexual and relationship violence and stalking to students, staff and faculty. To reach staff during office hours when the university is open or to reach an advocate after hours, call 848-932- 1181.

Disability Services

The Office of Disability Services phone number is (848) 445-6800, and it is located at Lucy Stone Hall, Suite A145 Livingston Campus 54 Joyce Kilmer Avenue Piscataway, NJ 08854

Rutgers University welcomes students with disabilities into all of the University's educational programs. In order to receive consideration for reasonable accommodations, a student with a disability must contact the appropriate disability services office at the campus where you are officially enrolled, participate in an intake interview, and provide documentation at Office of Disability Services Documentation Quidelines website. If the documentation supports your request for reasonable accommodations, your campus's disability services office will provide you with a Letter of Accommodations. Please share this letter with your instructors and discuss the accommodations with them as early in your courses as possible. To begin this process, please complete the Registration Form.

Scarlet Listeners

Scarlet Listeners provides free and confidential peer counseling and referral hotline, providing a comforting and supportive safe space. Call at (732) 247-5555 for more information.